screening cascade (HARTMANN GROUP)
90
Structured Review
HARTMANN GROUP
screening cascade
Screening Cascade, supplied by HARTMANN GROUP, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/screening+cascade/screening+cascade/pm23688131-158-3-14
Average 90 stars, based on 1 article reviews
Screening Cascade, supplied by HARTMANN GROUP, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/screening+cascade/screening+cascade/pm23688131-158-3-14
Average 90 stars, based on 1 article reviews
screening cascade - by Bioz Stars,
2026-09
90/100 stars
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other:Article Title: Progress towards clinically useful aldosterone synthase inhibitors. Article Snippet: Owing to the high degree of similarity between aldosterone synthase (CYP11B2) and cortisol synthase (CYP11B1), the design of selective inhibitors of one or the other of these two enzymes was, at one time, thought to be impossible.. Through development of novel enzyme screening assays and significant medicinal chemistry efforts, highly potent inhibitors of CYP11B2 have been identified with selectivities approaching 1000-fold between the two enzymes.. Many of these molecules also possess selectivity against other steroidogenic cytochromes P450 (e.g. CYP17A1 and CYP19A1) as well as hepatic drug metabolizing P450s. |